Thermal cyclers, or PCR machines, amplify DNA by regulating temperature in cyclical programs. A crucial tool in molecular applications, these highly specialized instruments progressively enjoy advancements in design and mechanics over time, such as enhances in lid security, heat block reliability, hardware functionality and more. Blocks become easily interchangeable to accommodate various sample formats, such as single tubes, strip wells, and multi-well tubes. Some models also feature dual or multi blocks that operate independently to handle multiple, simultaneous experiments. The temperature range is an important feature to consider when selecting a thermocycler, with 4°C-99°C being most common. More complex instruments cool down to as low as 0°C, a feature that is important when considering sample retention time. Programmable heated lids are an important feature that minimizes liquid evaporation, to ensure heat is evenly applied in sensitive PCR reactions. Increasingly, thermal cyclers are offering various levels of connectivity, with some models including USB ports and internet access for data sharing and remote access. To evaluate various thermocycler options such as specifications, features and cost, browse through our listing, curated from the leading manufacturers.